In consistent with this notion, animal experiments showed that a high intake of LA increased both AOM-and Apc mutation-induced CRC, suggesting its potential adverse effect on CRC (Reddy et al., 1985; Wu et al., 2004; Fujise et al., 2007; Enos et al., 2016; Liu et al., 2020). Here, APC is linked to colorectal carcinoma.