Gallic acid, which is a phenolic acid widely found in plants, has been shown to increase the risks of CRC in ApcMin/+p53R172H mice (ApcMin/+ mice with p53 mutation), while it had no effects on ApcMin/+ mice that express wild-type p53 (Kadosh et al., 2020). The gene discussed is TP53; the disease is colorectal carcinoma.