Regarding these oncogenic signaling pathways, ceMs of UCEC, adrenocortical carcinoma (ACC), and COAD function in the p53 signaling pathway, ceMs of UCEC, and esophageal carcinoma (ESCA) function in the Ras-MAPK and mTOR signaling pathways, and ceMs of brain lower grade glioma (LGG), lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), LUSC, COAD, and UCEC function in the PI3K-AKT signaling pathway (Figure 5D and Supplementary Figure 6). The gene discussed is TP53; the disease is adrenal cortex carcinoma.