NLRP3 and columnar cell hyperplasia of the breast: To determine whether autophagy is involved in the activation of the NLRP3 inflammasome and its possible mechanism in CCH, Shao-Hua Su et al. conducted a series of studies and found that CCH caused proinflammatory cytokine release, lysosome dysfunction, and autolysosome accumulation, resulting abnormal autophagy (Su et al., 2017, 2018).