NLRP3 and major depressive disorder: CQ, an autophagy flux blocker, could attenuate the antidepressant and anti-inflammatory effect of andrographolide, suggesting that andrographolide might ameliorate depression by inhibiting NLRP3 inflammasome-mediated inflammatory injury through inducing autophagy in CUMS mice, which needs further study (Geng et al., 2019).