The autophagy inhibitor 3-MA and lysosome inhibitor CQ could neutralize the effects of URB597 on the CCH-induced NLRP3 inflammasome, suggesting that URB597 alleviated CCH-induced NLRP3 inflammasome activation through promoting restoring CCH-inhibited lysosomal function of autophagy. The gene discussed is NLRP3; the disease is columnar cell hyperplasia of the breast.