OxLDL, mechanical stress, and estrogen all have an inductive effect on BMP2 (Cola et al., 2004; Osako et al., 2010; Su et al., 2011; Rutkovskiy et al., 2019), whereas shear stress, hyperglycemia, hyperlipidemia, and oscillatory shear stress enhance BMP4 (Sorescu et al., 2004; Csiszar et al., 2009). This evidence concerns the gene BMP4 and Hyperglycemia.