The depletion of estrogen receptor α (ERα) affects the biomechanical properties of Breast cancer (BC) cells, which is related to the decrease of cytoskeletal proteins (F-actin, FLNA, and α-tubulin) and cytoskeletal regulatory proteins (Rho, Rac1, and Cdc42) (27). This evidence concerns the gene ESR1 and breast carcinoma.