Very recently, Peng X et al. has reported that miR-1258 overexpression inhibits cell proliferation, invasion and migration by targeting the E2F1 and altering AKT and P53 signal pathway in cervical cancer (42), which also highlights a wide regulatory network of miR‐1258/E2F1 axis in cancers. The gene discussed is E2F1; the disease is cervical cancer.