Consistent with these data, we found that the KDM2A and PFKFB3 protein levels were significantly correlated with the ISS (International Staging System) stage of multiple myeloma, but not with other clinicopathological parameters (Table 1), which indicated that KDM2A and PFKFB3 may play a role in MM progression. This evidence concerns the gene KDM2A and plasma cell myeloma.