To deeply explore the specific mechanism of CXCL1 in CRC, we applied bioinformatics analysis and found 4 miRNAs (miR-302e, miR-520a-3p, miR-520c-3p, miR-520d-3p) that might target CXCL1 (Figure 4A). This evidence concerns the gene CXCL1 and colorectal carcinoma.