CXCL1 and colorectal carcinoma: Subsequently, miR-302e was overexpressed in SW480 cells (with the highest CXCL1 expression), finding that miR-302e overexpression prominently decreased the expression of CXCL1 mRNA and proteins, which indicated that CXCL1 might be negatively modulated by miR-302e in CRC cells (Figure 4E).