A meta-analysis assessed chemokine levels in patients with MDD without medical disease and found that peripheral blood CCL2, CCL3, CCL11, CXCL7, and CXCL8 levels were higher and CCL4 levels were lower than control, while no significant differences were found in other chemokines (CCL5, CCL7, CXCL9, CXCL10, and cerebrospinal fluid CXCL8 and CXCL10) [31]. Here, CXCL8 is linked to major depressive disorder.