The recruitment of these two linker proteins activates the transcription factors, nuclear factor kappa-B, transcriptional activator AP-1, and interferon regulatory factor 3, induces production of the pro-inflammatory factors IL-β, TNF-α, IL-6, and CXCL10, upregulates the expression of COX-2, eventually activates the inflammatory response, and participates in the pathogenesis of MDD [69]. Here, IL6 is linked to major depressive disorder.