The involvement of chemokines in the occurrence of depression may be related to the following mechanisms: CCL2 participates in monocyte migration; CCL2, CCL3, and CXCL10 take part in the changes of neurotransmission and cognitive function [31,72,73]; CXCL8 and CXCL10 are involved in neuroendocrine regulation, which is related to the change in HPA axis function [31,74]. This evidence concerns the gene CXCL8 and major depressive disorder.