This analysis revealed 13 novel mutations in HFM-associated NID2, PARD3B, CACNA1C, ERC1, IQSEC3, LZTR1, MED15, PLCD3, SALL4, SCR1B, SHROOM3, SLC6A13, and TCOF1, which collectively affected 14 (26.92%) of the analyzed patients (Figure 2A). The gene discussed is MED15; the disease is craniofacial microsomia.