Besides these short-distance effects, there are long-range effects that involve the immune response activation through the production/release by irradiated cells of pro-immunogenic factors, such as tumor antigens (54), Natural Killer (NK) receptor G2D (NKG2D) ligands that act as danger signals to alert NK cells (55), and through the recruitment of CD8+ T cells and myeloid cells (56) together with the production of type I Interferon (IFN) (57). This evidence concerns the gene CD8A and neoplasm.