Similarly, among the 30 hub genes in SLE, 12 genes (OAS1, RSAD2, OASL, IFIT3, OAS2, IFIH1, CENPE, TOP2A, PBK, KIF11, IFIT1, and ISG15), which had AUC above 0.70 were appraised as biomarker genes, because they can be used to specifically diagnose SLE patients with high sensitivity (Figure 12). This evidence concerns the gene ISG15 and systemic lupus erythematosus.