TOP2A and systemic lupus erythematosus: Similarly, among the 30 hub genes in SLE, 12 genes (OAS1, RSAD2, OASL, IFIT3, OAS2, IFIH1, CENPE, TOP2A, PBK, KIF11, IFIT1, and ISG15), which had AUC above 0.70 were appraised as biomarker genes, because they can be used to specifically diagnose SLE patients with high sensitivity (Figure 12).