CCL2 and neoplasm: Therapies that deal with macrophages mainly consists of two approaches, those that deplete TAMs in an effort to prevent their tumor supporting functions (chemokine (C-C motif) ligand 2 (CCL2) or CC‐chemokine receptor 2 (CCR2) blockade, which prevents their recruitment into tumors, for example), and those that try to repolarize them towards an M1-like antitumor phenotype (115).