The top immune-related genes uniquely upregulated in febrile DF (as compared to convalescence) were IFIT1, IFI44L, HAVCR2 (Tim3) while those uniquely upregulated in febrile DHF were GZMB, SLAMF7, RORC, TRIM21, and IL15RA. (Figure 5F, Supplementary Figure 1B, D and 2 and Supplementary Tables 6, 7). This evidence concerns the gene TRIM21 and dengue disease.