Our data collectively highlights that (i) ZIKV infection in SC primarily impacts pathways involved in innate antiviral defense and IFN signaling, (ii) the top upregulated proteins during ZIKV infection in SC are encoded by the ISGs MX1 and IFIT1, (iii) both MX1 and IFIT1 serve as antiviral effectors against ZIKV in SC, and (iv) the IFN-I response in SC specifically restricts ZIKV infection but is dampened as compared to A549 cells and BMVEC. The gene discussed is MX1; the disease is Zika virus infectious disease.