IFNB1 and Zika virus infectious disease: To investigate this, we next compared the induction of ISGs in SC to that of A549 human lung epithelial cells and human brain microvascular endothelial cells (HBMVEC), which are two cell types also shown to be permissive to ZIKV infection (Siemann et al., 2017; Kumar et al., 2018), following stimulation with IFN-β.