To investigate, SC were pretreated with 5 pg/mL (1 IU/mL) of recombinant human IFN-β for 24 h prior to infection (MOI 1) and ZIKV replication as well as MX1 and IFIT1 expression were then evaluated by RT-qPCR at 48 h post-infection. This evidence concerns the gene IFIT1 and infection.