IFNA1 and infection: In general, ZIKV is shown to strongly trigger IFN response in many human cell types, including skin fibroblasts, Hofbauer cells, dendritic cells, macrophages, and A549 cells, by as early as 24 h post-infection (Hamel et al., 2015; Quicke et al., 2016; Bowen et al., 2017; Carlin et al., 2018; Zimmerman et al., 2018; Esser-Nobis et al., 2019).