INS and type 2 diabetes mellitus: Similarly, genetic studies of T2D identified many single nucleotide polymorphisms (SNPs) associated with T2D risk, which are located near several functionally relevant genes such as PPARG (8), WFS1 (9), KCNJ11 (10), KLF14 (9), ANK1 (11), INS (12), HNF1A (9), HNF1B (13), and GLIS3 (14).