A more systematic analysis of pancreatic transcription factors PDX1, RFX6, PTF1A, GLIS3, MNX1, NGN3, HES1, and ARX, partly identified in monogenic variants of MODY and PNDM, characterized the transcriptional control and corresponding defects at several developmental stages (86). This evidence concerns the gene GLIS3 and permanent neonatal diabetes mellitus.