One of the potential causes is that the mineralocorticoid receptors, with high bonding affinity with both mineralocorticoids and glucocorticoids, were reported to be involved in the maturation of pre-adipocytes to adipocytes (34), which could be associated with the higher prevalence of hyperglycemia among PA patients over patients with EH (39). This evidence concerns the gene NR3C2 and Hyperglycemia.