MAPT and Alzheimer disease: In addition, most studies indicate that Tau is involved in the neurodegeneration associated with oxidative stress in AD: in a Drosophila model of human tauopathy (Tau R406W), a reduction in the gene dosage of thioredoxin reductase or mitochondrial superoxide dismutase 2 (SOD2) promotes Tau-induced neurodegenerative histological abnormalities and neuronal apoptosis.