And our results also found that the expression level of Trx-1 was reduced in the hippocampus of mice in the TG-DM group compared with the TG-NC group (see Figure 1) and which is consistent with the results reported above, and the extent of ASK1 phosphorylation was also attenuated in TG-DM compared with WT-DM, Trx-1 may play a key role in AD through the regulation of ASK1 (see Figure 5). Here, MAP3K5 is linked to Alzheimer disease.