MAP3K5 and Alzheimer disease: It has also been reported that the expression of Trx-1 is reduced in AD, a fact that suggests that the reduced level of Trx-1 may be related to the neurodegenerative mechanisms of AD: its reduction may contribute to the neurodegenerative mechanisms of AD, which may be related to the interaction of Trx-1 with ASK1 (Akterin et al., 2006).