TNF and cancer: Outside the field of cancer, especially in rheumatism, TNF has been identified as a major regulator of inflammation and a key participant in the cytokine network, which has led to the development of antagonists of its role and revolutionized the treatment of rheumatoid arthritis and other inflammatory diseases (Tracey et al., 2008; Billmeier et al., 2016; Green et al., 2019).