It participates in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis; the expression of IL-1 targets that promote tumor angiogenesis in chronic inflammation, and the expression of soluble mediators in cancer-related fibroblasts (CAFs) that cause antiapoptotic signals in tumor cells, thus promoting tumor progression (Bent et al., 2018). This evidence concerns the gene IL1B and neoplasm.