LGALS3 and multiple sclerosis: Similarly to Gal-3, Gal-9 also appears to serve several roles in the immune response of nervous systems, namely at the astrocyte-microglia interface (Steelman et al., 2013; Steelman and Li, 2014), the microglia response during multiple sclerosis (Stancic et al., 2011), and toxoplasmic encephalitis in mice (Liu et al., 2018).