Recently, supporting a Gal-3 pro-inflammatory role in the retina, Mendoca et al. showed that diabetes-induced neuroinflammation of the optic nerve tissue is strongly reduced in Gal-3 −/− mice, manifested by a reduction in iNOS and GFAP and improved axon myelination (Mendonça et al., 2018). The gene discussed is LGALS3; the disease is diabetes mellitus.