Notably, the majority of published data suggest that excessive Ca2+ influx through Orai1/SOCE is a causative factor for pathological cardiac hypertrophy (Hunton et al., 2002; Ohba et al., 2009; Voelkers et al., 2010; Hulot et al., 2011; Luo et al., 2012; Wang et al., 2015; Zheng et al., 2017; Bartoli et al., 2020). This evidence concerns the gene ORAI1 and cardiac hypertrophy.