In pathological states such as sepsis, cardiac arrhythmia associated with hypertension and chronic obstructive lung diseases, Wnt5A signaling is activated in the cardiovascular system (Pereira et al., 2008; Schulte et al., 2012; Daud et al., 2016; Abraityte et al., 2017a; Baarsma et al., 2017; Abraityte et al., 2017b). This evidence concerns the gene WNT5A and chronic obstructive pulmonary disease.