APP and Alzheimer disease: IPA analyses identified MAPT (microtubule associated protein tau), RICTOR (rapamycin-insensitive companion of mammalian target of rapamycin), TLE3 (Transducin-like enhancer protein 3), PSEN1 (Presenilin 1) and APP (amyloid precursor protein) as the top five Upstream Regulators driving the proteomic changes between AD (high CAA score) vs. aged-matched controls (Figure 6E).