CLPP and early-onset autosomal dominant Alzheimer disease: IPA analyses identified MAPT (microtubule associated protein tau), CLPP (Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit), KDM5A (Lysine-specific demethylase 5A) and APP (amyloid precursor protein) as the top four Upstream Regulators driving the proteomic changes between low vs. high CAA Alzheimer's disease cerebrovascular tissue (Figure 7E).