Receptors to orexin, a neuropeptide with important roles in reinforcing properties of drugs of abuse (Martin-Fardon and Boutrel, 2012), are found throughout the PVT, and blockade of these receptors in rats decreases anxiety-like behavior in the elevated plus-maze (Heydendael et al., 2011) but does not affect expression of conditioned fear (Dong et al., 2015). Here, HCRT is linked to Anxiety.