In addition, microinjection of orexin into the pPVT increases avoidance and anxiety-like behaviors (Li et al., 2010a, b) whereas microinjection into the aPVT increases consumption of ethanol, but not sucrose (Barson et al., 2015), indicating that the role of orexin in the PVT may vary based on anatomical location. Here, HCRT is linked to Anxiety.