This assumption is supported by the fact that both PSMC3IP and RAD54L are important contributors to homologous recombination repair [51, 52], and have a higher association with overall survival in patients treated with radiotherapy as compared to the total HNSCC TCGA cohort of patients who received heterogenous treatment (Supplementary Fig. 6A and B). The gene discussed is RAD54L; the disease is head and neck squamous cell carcinoma.