PSMC3IP and head and neck squamous cell carcinoma: This assumption is supported by the fact that both PSMC3IP and RAD54L are important contributors to homologous recombination repair [51, 52], and have a higher association with overall survival in patients treated with radiotherapy as compared to the total HNSCC TCGA cohort of patients who received heterogenous treatment (Supplementary Fig. 6A and B).