Analysis of the 77 CSC-related genes revealed a strong correlation of POU5F1, PSMC3IP, and RAD54L with CHEK-1, WEE1, and TAZ, the critical regulators of the homologous recombination, cell cycle, and CSC maintenance in the HNSCC TCGA patient dataset (Fig. 6A). This evidence concerns the gene CHEK1 and head and neck squamous cell carcinoma.