Recently, Kessler et al. showed an induction of paraspeckles in sorafenib-resistant HCC and purposed paraspeckle-associated protein NONO, PSPC1, and RBM14 might be promising targets [38], which strengthened our view about the importance of NONO in sorafenib resistance of HCC. This evidence concerns the gene RBM14 and hepatocellular carcinoma.