What’s more, HIF-1ɑ (r = 0.39, p = 3.6e-15) and HIFs target genes VEGF (r = 0.41, p = 4.4e-16), GLUT1 (r = 0.38, p = 1.9e-14), LDHA (r = 0.4, p = 4.4e-16), ENO1 (r = 0.44, p = 0), and LOXL2 (r = 0.33, p = 9.7e-11) showed a positive correlation with the expression of NONO in the TCGA HCC provisional cohort (Fig. 3E), further confirming our findings. The gene discussed is ENO1; the disease is hepatocellular carcinoma.