Loss of Lnc-408 led to decreased p-CREB, p-cofilin, MMP2, ITGB1, and COL1A1 protein levels, and ectopic LIMK1 restored p-CREB, p-cofilin, MMP2, ITGB1, and COL1A1 protein levels in Lnc-408-silenced Hs578T and PL-BC-05 cells; similarly, ectopic Lnc-408 in MCF-7 cells enhanced p-CREB, MMP2, ITGB1, and COL1A1 expression, and knockdown of LIMK1 attenuated the Lnc-408-induced increase in these proteins in MCF-7 cells (Figs. 6C, D and S7B–D). Here, CREB1 is linked to breast cancer.