LIMK1 and breast cancer: To confirm the role of Lnc-408/LIMK1 signaling in tumor invasion, a set of engineered BC cells were established (Hs578T/Control, Hs578T/sh Lnc-408, and Hs578T/sh Lnc-408/LIMK1; PL-BC-05/Control, PL-BC-05/sh Lnc-408, and PL-BC-05/sh Lnc-408/LIMK1; PL-BC-05/Control, PL-BC-05/KO Lnc-408, and PL-BC-05/KO Lnc-408/LIMK1; MCF-7/Control, MCF-7/Lnc-408, MCF-7/Lnc-408/shLIMK1) (Figs. 6A, B and S7A).