Lnc-408 could upregulate LIMK1 by serving as a sponge for miR-654-5p, which enhances the invasiveness and metastatic capacity of BC cells by activating p-cofilin/F-actin and p-CREB and downstream targets (MMP2/ITGB1/COL1A1). The gene discussed is ITGB1; the disease is breast cancer.