Interrogating the Pan Cancer Analysis of Whole Genomes (PCAWG) dataset40, we observed, among 377 colon adenocarcinoma tissue samples, a trend for the enrichment of Claudin-2 expression in samples associated with a microsatellite instablility (MSI) phenotype relative to the microsatellite stable subtype (MSS) (Fig. 2c)41. The gene discussed is CLDN2; the disease is cancer.