PTEN and neoplasm: PTEN (Phosphatase and Tensin homolog on chromosome Ten, OMIM #601728), a well-studied, tumor suppressor gene, is known for its canonical role as the major antagonist of PI3K/AKT/mTOR signaling, a crucial growth and survival intracellular cascade, via the lipid modality of PTEN’s dual-specific phosphatase function1–3.