MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease (AD) is one of the most common age-related neurodegenerative diseases, and includes the pathological hallmarks of extracellular amyloid plaques by abnormally folded amyloid-β 42 (Aβ-42) and intracellular neurofibrillary tangles (NFTs) by Tau hyperphosphorylation in the brain1,2.