Conversely, the inhibition of NLRP3 inflammasomes increases STING1-dependent IFN production148, while the activation of NLRP3 or AIM2 in murine macrophages leads to the inactivation of the STING1 pathway149,150, suggesting a yet unknown mechanism to balance the activation of STING1 and inflammasomes in response to infection. This evidence concerns the gene STING1 and infection.