PIM1 and diffuse large B-cell lymphoma: In addition, PIM1 somatic mutation was identified as one of the potential early drivers of lymphomagenesis.19PIM1 (c.403G>A, p.Glu135Lys, legacy Identifier in COSMIC: COSM1161628) is frequently reported in DLBCL in somatic states, and this mutation was predicted to be damage by FATHMM and SIFT.