Oral delivery of IL-27 recombinant bacteria can ameliorate T cell transfer-induced colitis in mice (Hanson et al., 2014) whilst a T. muris infection in an IL-10/IL-27 KO mouse leads to less severe pathology than seen in the IL-10 KO control due to a decreased pro-inflammatory profile (Villarino et al., 2008). The gene discussed is IL10; the disease is colitis.