Specifically, it is known that a low-dose infection of ~20 T. muris eggs will proceed to chronicity (Fig. 1), even in normally resistant strains of mouse, leading to an IFN-γ/Th17-driven disease (Levison et al., 2010) that is controlled by a concomitant IL-10 response (Grencis et al., 2014). The gene discussed is IL10; the disease is infection.