LEP and depressive symptom measurement: Interestingly, earlier (Milaneschi et al., 2017b) and recent (Badini et al., 2020) large-scale genomic studies found that the genetic overlap between BMI, CRP and leptin with depression is symptom specific; this overlap was only found in depressed patients with increased hypersomnia (Badini et al., 2020), weight and appetite (Badini et al., 2020; Milaneschi et al., 2017b).