For example, bipolar disorder has been linked to impairment of glucose metabolism (de Melo et al., 2017), seasonal affective disorder with dysregulations of major metabolic regulator (i.e. adiponectin) (Akram et al., 2020), and sickness behavior with immuno-metabolic alterations (Capuron & Miller, 2011). Here, ADIPOQ is linked to bipolar disorder.