Although previous studies have shown that rTMS may suppress the expression of APP and APP cleavage enzyme, β-secretase 1 (BACE1), therefore reduce the production and processing of Aβ in the AD mouse brains [27], however, merely reducing Aβ production may not be sufficient for the pathological improvement and cognitive benefits observed in rTMS-treated AD animal models and patients. This evidence concerns the gene BACE1 and Alzheimer disease.