Several factors involved in kidney disease pathogenesis (e.g., oxidative stress, inflammation) induce PAI-1 expression (66, 70, 71), which in turn has been linked to fibrosis, glomeruli damage and other pathogenic mechanisms in renal disease [65, 67], as well as to thrombosis and an increased hypercoagulable state—a shared phenotype of inflammaging [37] and renal disease [72]. Here, SERPINE1 is linked to kidney disorder.