NUCLEOLIN and neoplasm: Altogether, these results demonstrate that cell surface NCL might be used for the selective targeting of NB cells, through intravenous administration of nanoparticles encapsulating not only chemotherapeutic agents, but also retinoids or macromolecules like siRNA or miRNA mimics molecules, specific for NB oncogene silencing or for tumor suppressor miRNA replacement, respectively, as previously demonstrated [15, 23, 26].