We found that mucosal epithelial cells of children with IBD (Fig. 1) or those of DSS treated mice (Fig. 2) and also HT-29 colon epithelial cells (Fig. 3) express IL-20RB, the common IL-24 binding subunit of the IL-20RA/IL-20RB or IL-22RA/IL-20RB receptor heterodimers. This evidence concerns the gene IL20RB and inflammatory bowel disease.