Thirty-nine differentially expressed genes (DEGs), with 36 up-regulated (ACSL3, ACSL4, AGPAT2, BSCL2, CAV1, CAV2, CAVIN1, CES1, CIDEC, DGAT1, DGAT2, FAF2, G0S2, HILPDA, HSD17B11, ICE2, LDAH, LIPE, LPCAT1, LPCAT2, LPIN1, MGLL, NAPA, NCEH1, PCYT1A, PLIN3, RAB5A, RAB7A, RAB8A, RAB18, SNAP23, SQLE, VAPA, VCP, VMP1) and 3 down-regulated genes (FITM1, PLIN4, PLIN5) were identified in bulk pancreatic cancer as compared to normal pancreatic tissues (Fig. 1). This evidence concerns the gene ICE2 and familial pancreatic carcinoma.