A retrospective study encompassing 349 Spanish HSP patients and 335 sex ethnically matched controls by López-Mejías et al. [9] identified that HLA-B*41:02 was subjected to a 5.5-fold increase in HSP patients as compared with controls and was related to the susceptibility to HSP (OR = 5.8). This evidence concerns the gene HLA-B and hereditary spastic paraplegia.