On the other hand, the analysis revealed that the 50 LncRNAs that were downregulated in steatosis and upregulated upon Ex-4 exposure were significantly associated with essential processes and molecular pathways, including insulin, PPAR, Wnt, mTOR, p53, TGF-β, VEGF, NOD-like, and Toll-like receptors signaling pathways as well as pyruvate metabolism and type 2 diabetes (Fig. 5). This evidence concerns the gene PPARA and type 2 diabetes mellitus.