In this regard, exosomes from glioblastoma (GBM)-derived stem cells (GSCs) were shown to traverse the monocyte cytoplasm, causing a reorganization of the actin cytoskeleton, and skew monocytes toward the immunosuppressive M2 phenotype, including programmed death-ligand 1 (PD-L1) expression [87]. The gene discussed is CD274; the disease is glioblastoma.