CD274 and neoplasm: Others have shown that the paired expression of PD-1; PD-L1 on DCs is correlated with the tumor progression, loss of positive costimulatory markers (CD80, CD86, and CD40), a lack of cytokine release (IL-12, IL-10, IL-6, TNFα, and G-CSF), and contact-dependent inhibition of T cell expansion [78, 89].