It has been shown that PGE2 and TGF-β, both present in TDEs, are also critically involved in the abrogated function of tumor-associated DCs via the upregulation of ARG1 activity, IDO, and co-inhibitory molecule B7-H1 and B7-DC, as well as the IL-10 production [33, 104]. This evidence concerns the gene TGFB1 and neoplasm.