Apart from a small decrease in triglycerides (− 0.15 mmol/l; − 0.29, − 0.01) in WAP at 48 months and a reduction in liver enzymes alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in WA, there was no other clear pattern of differences between groups in clinical outcomes, depression or quality of life. The gene discussed is GPT; the disease is major depressive disorder.