TNF and lymphopenia: Besides, a study showed that severe infection by SARS-CoV-2 could create lymphopenia with decreased CD4+ and CD8+, but interestingly, there is no decrease in lymphocytes B. In summary, there is an increase in cytokines IL6, IL2R, IL10, TNFα, and MCP-2 production and a decrease in IFN-γ production [95].