KCNMA1 is the main subunit forming the large-conductance potassium channel (BK channel), the activity of which is elevated in fibroblasts from patients with IPF and can affect the expression of αSMA by increasing intracellular calcium, required for myofibroblast differentiation leading to lung fibrosis.39 The gene discussed is KCNMA1; the disease is pulmonary fibrosis.