Finally, as FA significantly enhanced the Sirt1/AMPK/PGC‐1α signaling pathway, we investigated whether suppression of SIRT1 activity by Sirtinol, a SIRT1 inhibitor, could abolish the protective effects of FA on IL‐1β‐induced degeneration of osteoarthritis chondrocytes. This evidence concerns the gene PPARGC1A and osteoarthritis.