We found that, compared to cells treated with both IL‐1β and FA, osteoarthritis chondrocytes treated with IL‐1β, FA, and Sirtinol showed increased nitrite production (Figure 6A), increased PGE2 production (Figure 6B), increased mRNA levels of Collagen I (Figure 6C) and Runx‐2 (Figure 6F), decreased mRNA levels of Collagen II (Figure 6D) and Aggrecan (Figure 6E), and promoted MMP‐1 (Figure 6G), MMP‐3 (Figure 6H), and MMP‐13 (Figure 6I) mRNA expression. The gene discussed is ACAN; the disease is osteoarthritis.