The main metabolic effects of adiponectin include glucose and lipid metabolism regulation through fatty acid oxidation stimulation, suppression of hepatic glucose production, and increased insulin sensitivity in liver and muscle tissue.2, 3In contrast to other hormones secreted by the adipose tissue, its serum level decreases as adiposity increases and are negatively correlated with obesity, insulin resistance, and metabolic syndrome.1, 4Furthermore, it presents other roles, presenting antihyperglycemic, antiatherogenic and anti-inflammatory properties.5, 6. The gene discussed is ADIPOQ; the disease is Insulin resistance.