HSP90AB1 and cancer: Through the folding and stabilization of several hundred substrates, termed client proteins, HSP90 modulates many cellular processes beyond proteostasis, including signal transduction, DNA repair, and immune response, that are important in several diseases, such as cancer, neurodegenerative conditions, inflammation, and infection (Butler et al., 2015; Shrestha et al., 2016; Taipale et al., 2010; Workman, 2020).