INS and type 2 diabetes mellitus: In our review of the T2D studies that showed glycemic benefits with insulin pump use, we found two early studies that demonstrated improved outcomes in individuals with T2D who were treated insulin pump therapy after earlier treatment with less-intensive insulin therapy or oral medications.36,38 Although recent studies, such as the OpT2mise trial,34,35 listed prior MDI therapy in their inclusion criteria, this requirement was for study purposes only.