Thus, based on its nematodicidal spectrum of activity [26], its strong activation of, and high affinity for, the nematode drug target SLO-1 over the mammalian ortholog [38,39], and moreover, its resistance-breaking properties [31,32], emodepside is considered to be one of the most promising developmental candidates for the treatment of human onchocerciasis and soil-transmitted helminthiases [40–43]. This evidence concerns the gene KCNMA1 and onchocerciasis.